first whispered in the comments seems to be coming true: this notice posted in the window of the now-vacated Tuggey's Hardware indicates that 1 Life Healthcare (aka One Medical) will take over the space. Permit #201205150522 at the DBI confirms that 3885 24th St will be built out as medical offices. One Medical currently operates at 3901 23rd St at Sanchez.
Probably great news for Dennis Giovannoli's retirement. Not so good news for the vibrancy of the 24th St retail/restaurant scene.